采用大鼠纹状体微量透析法，研究了烟碱对儿茶酚胺及吲跺胺类含量的影响．结果表明，烟碱可促进中枢纹状体中的二羟基苯乙酸、３－甲氧－４－羟基苯甲醛酸、多巴胺及５－羟基吲哚乙酸的释放．烟碱的这一作用，可被中枢性抗胆碱药美加明所抑制，但却不能被外周作用的抗胆碱药六烃季胺所抑制，从而说明烟碱的作用是其对中枢的直接作用． The rat striatum microdialysis method was used to study the effect of nicotine on the content of catecholamines and indamines. The results showed that nicotine can promote the release of dihydroxyphenylacetic acid, 3-methoxy-4-hydroxybenzaldehyde, dopamine and 5-hydroxyindoleacetic acid in the central striatum. This effect of nicotine, which is inhibited by central anticholinergic mecamylamine but not by the peripherally acting anticholinergic quaternary ammonium, suggests that nicotine’s effect is its direct effect on the central nervous system.