This study examined the association of polymorphisms in angiotensinⅡreceptor genes(AT1R and AT2R) with the risk for aldosterone-producing adenoma(APA) in a Chinese Han population.Four polymorphisms including rs5182(573T/C) in exon 4,rs5186(1166A/C) in 3’-untranslated region(3’-UTR) in AT1R gene and rs5194(2274G/A) in 3’-UTR,rs1403543(1675G/A) in intron 1 in AT2R gene were detected in 148 APA patients and 192 normal subjects(serving as control) by using a MGB-Taqman probe.The distribution of genotypes of each locus was in accordance with Hardy-Weinberg Equilibrium(HWE) in the APA and control groups(P>0.05).The allele A frequency at rs5194 was significantly higher in the APA group(0.49) than in the control group(0.35)(χ2=12.08,P=0.001).Subjects with homozygotic genotype AA and heterozygotic genotype GA were at an increased risk for APA as compared to those with GG genotype(OR=2.66,95% CI=1.45-4.87;OR=1.67,95% CI=1.02-2.74).Furthermore,rs5194 single-nucleotide polymorphism(SNP) at AT2R gene was significantly associated with APA in additive(OR=1.64,95% CI=1.21-2.20,P=0.001),dominant(OR=1.94,95% CI=1.23-3.06,P=0.003),and recessive model(OR=2.01,95% CI=1.17-3.45,P=0.01).It was concluded that rs5194 polymorphism at AT2R gene was associated with the risk for APA,which may constitute a genetic marker of APA. This study examined the association of polymorphisms in angiotensin II receptor genes (AT1R and AT2R) with the risk for aldosterone-producing adenoma (APA) in a Chinese Han population. Four polymorphisms including rs5182 (573T / C) in exon 4, rs5186 ) in1tron 1 in AT1R gene and rs5194 (2274G / A) in 3’-UTR, rs1403543 (1675G / A) intron1 in AT2R gene were detected in 148 APA patients and 192 normal subjects (serving as control) by using a MGB-Taqman probe. The distribution of genotypes of each locus was in accordance with Hardy-Weinberg Equilibrium (HWE) in the APA and control groups (P> 0.05). The allele A frequency at rs5194 was significantly higher in the APA group (0.49) than in the control group (0.35) (χ2 = 12.08, P = 0.001). Subjects with homozygotic genotype AA and heterozygotic genotype GA were at an increased risk for APA as compared to those with GG genotype (OR = 2.66, 95% CI = 1.45-4.87; OR = 1.67,95% CI = 1.02-2.74) .Furthermore, rs5194 single-nucleotide polymorphism (SNP) at AT2R The gene was significantly associated with APA in additive (OR = 1.64, 95% CI = 1.21-2.20, P = 0.001), dominant (OR = 1.94, 95% CI = 1.23-3.06, P = 0.003) = 2.01, 95% CI = 1.17-3.45, P = 0.01) .It was that that rs5194 polymorphism at AT2R gene was associated with the risk for APA, which may constitute a genetic marker of APA.