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采用硬模板法制备了尺寸约为300 nm,外壳厚度约25 nm的中空介孔二氧化硅球(HMSNs),通过溶剂浸渍法将易挥发药物冰片包载其中,以期解决冰片的药剂学稳定问题,并利用BET,TEM,FT-IR等对HMSNs以及载药体系进行了表征,考察了载药体系的最佳载药时间,最大载药量以及冰片的挥发状况。研究结果显示,室温、中性条件下制备的HMSNs球形度良好,可以在较短的时间内实现对冰片较大的载药量,6 h内载药量高达74.04%,同时体系中冰片的挥发性得到了很大程度的改善。该新型载药体系的研究为冰片在中药制剂中的广泛应用提供了新思路。
Hollow mesoporous silica spheres (HMSNs) with a size of about 300 nm and a shell thickness of about 25 nm were prepared by a hard template method. Solvent impregnation method was used to encapsulate the volatile drug borneol in order to solve the problem of the pharmacological stability of the borneol HMSNs and drug loading systems were characterized by BET, TEM, FT-IR and so on. The optimum drug loading time, the maximum drug loading and the volatilization status of borneol were investigated. The results showed that HMSNs prepared at room temperature and under neutral conditions had a good sphericity, which could achieve a large loading of borneol in a short time, up to 74.04% in 6 h, while the volatilization of borneol Sex has been greatly improved. The new drug-loaded system provides a new idea for the wide application of borneol in traditional Chinese medicine preparations.