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目的:研究山大颜乙醇提取物的抗抑郁作用。方法:采用小鼠悬尾、强迫游泳、自主活动和利血平诱导抑郁症模型实验,研究山大颜醇提物的抗抑郁活性。结果:山大颜乙醇提取物(50、100、150mg.kg-1)能显著缩短小鼠悬尾和游泳不动时间(P<0.05)。山大颜中、高剂量组(100、150mg.kg-1)对利血平所致小鼠体温的下降和眼睑下垂有明显改善作用(P<0.05)。结论:山大颜乙醇提取物具有一定的抗抑郁作用。
OBJECTIVE: To study the antidepressant effects of ethanol extract from Da Yan Yan. Methods: Mice were suspended, forced swimming, spontaneous activity and reserpine-induced depression model experiments to study the antidepressant activity of Shannuo Yan extract. Results: The ethanolic extract (50, 100, 150 mg.kg-1) could significantly reduce the tail suspension and swimming time (P <0.05). Shan Da Yan medium and high dose group (100, 150mg.kg-1) on reserpine-induced mice decreased body temperature and eyelid ptosis significantly improved (P <0.05). Conclusion: Ethanol extract from Da Yuan Yan has certain antidepressant effects.