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目的探讨抑癌基因p16、p15在脑胶质瘤中的表达及其与胶质瘤病理分级、恶性程度的关系。方法应用免疫组化SP方法检测63例人脑胶质瘤手术标本中P16、P15蛋白的表达水平。结果P16、P15蛋白的表达率与脑胶质瘤的病理分级呈负相关,且低恶性组(Ⅰ~Ⅱ级)与高恶性组(Ⅲ~Ⅳ级)相比较有显著差异(P<0.001)。结论P16及P15蛋白的表达与胶质瘤的病理分级和恶性程度有关。从而可作为反映脑胶质瘤的增生能力及恶性进展的参考指标。
Objective To investigate the expression of tumor suppressor genes p16 and p15 in gliomas and their relationship with the pathological grade and malignancy of gliomas. Methods Immunohistochemical SP method was used to detect the expression of P16 and P15 proteins in 63 human glioma specimens. Results The expression of P16 and P15 protein was negatively correlated with the pathological grade of glioma. There was significant difference (P <0.001) between the low malignant group (grade Ⅰ ~ Ⅱ) and the high malignant group (grade Ⅲ ~ Ⅳ) . Conclusion The expression of P16 and P15 proteins is related to the pathological grade and malignancy of gliomas. Which can be used as a reflection of glioma proliferation and malignant progress of the reference index.