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甲壳类过敏无论在成人还是儿童发病率均较高。其临床表现可由单纯的口腔症状至过敏性休克不等，甚至在同一个体也可出现不同反应。由于过敏原氨基酸序列同源性的存在，导致出现不同程度的交叉反应。目前研究发现，实验室检查与临床表现有时并不相符，并且有学者提出，脱敏治疗可能会导致其他物质的过敏反应。另一方面，水产品加工所导致的职业性过敏也日益受到重视。该文就近期有关甲壳类过敏相关的研究进展予以综述。“,”Shellfish is one of the most common causes of food allergy in the world in both adults and children.Its clinical manifestations can range from isolated oral allergic symptoms to allergic shock , and sometimes even within the same individual.Because there is high molecular(amino acid) homology between the allergens,cross-reactivity across the molluscan and crustacean is well established.The recent findings showed that IgE cross-reactivity may not translate to overt clinical allergy,and the patients,receiving some immunotherapy,developed IgE against other substances.On the other hand,occupational allergy,affecting seafood-processing workers is drawing more attention as well.Here is to make a review of the research on shellfish allergy.