1980年1例60岁女患者,因患粉刺型乳腺癌切除了左侧乳房。1983年4月X线胸片证实有多发性肺转移,于4月4日用~(99m)Tc—MDP注射液进行了放射性同位素骨扫描,扫描结果显示胸廓、腰椎和右坐骨有多发转移灶。注射~(99m)Tc—MDP 48小时后,患者感到咽部刺痛,并有突起的红斑疹,伴咽部溃疡,症状持续了3～4天。1984年2月16日,该患者进行了第二次~(99m)Tc—MDP骨扫描检查,显示有新的骨转移灶, A 60-year-old female patient in 1980 with a left breast removed due to acne-prone breast cancer. April 1983 X-ray confirmed multiple lung metastases, on April 4 with ~ (99m) Tc-MDP injection of radioisotope bone scan, the scan showed that the thoracic, lumbar and right ischial multiple metastases . Forty-eight hours after injecting ~ (99m) Tc-MDP, the patient felt pharyngeal stinging and had a prominent erythema with a pharyngeal ulcer. The symptoms lasted for 3 to 4 days. On February 16, 1984, a second ~ (99m) Tc-MDP bone scan was performed on the patient, showing a new bone metastasis,