观察不同剂量的扶桑花提取物在宫内注射大鼠的抗早孕效果．实验结果显示：（１）每侧子宫给予１０ｍｇ，２０ｍｇ和３０ｍｇ的石油醚提取物（ＨＲ１）后，子宫内死胚和损伤胚的百分率分别达到８１．６％，９２．０％和９９．０％，胚胎平均大小分别为０．３０ｃｍ，０．３１ｃｍ及０．１７ｃｍ，明显小于对照组的胚胎０．７５ｃｍ（Ｐ＜０．０１）．（２）给药各组的血清ＦＳＨ（）和雌二醇呈下降趋势，血清ＬＨ（）及孕酮水平仅在３０ｍｇ剂量组明显低于对照组（Ｐ＜０．０５）．这提示，ＨＲ１在大鼠的抗早孕作用与垂体和卵巢激素的降低有关 Observed the effect of different doses of hibiscus mulberry extract on intrauterine injection in rats against early pregnancy. The results showed that: (1) After 10 mg, 20 mg, and 30 mg of petroleum ether extract (HR-1) was administered to each uterus, the percentage of dead embryos and damaged embryos in the uterus reached 81.6%, 92.0%, and 99%, respectively. The average embryo size was 0.30 cm, 0.31 cm and 0.17 cm, respectively, which was significantly smaller than that of the embryos in the control group (0.75 cm, P<0.01). (2) The serum levels of FSH () and estradiol in each group showed a decreasing trend, serum LH () and progesterone levels were only significantly lower in the 30 mg dose group than in the control group (P<0.05). This suggests that the effect of HR1 on early pregnancy resistance in rats is related to the decrease of pituitary and ovarian hormones