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以河北、河南、辽宁、湖北四个化纤厂接触CS_2的已婚女工682人为观察对象,以同地区棉纺厂已婚女工745人为对照组,应用历史性前瞻的方法,进行了生育史的调查。接触组妊娠次数1112次,对照组为1494次。结果,子代出生缺陷发生率接触组为26.44‰,显著高于对照组(13.07‰),RR2.02,95%可信限1.13～3.60,P<0.025。在调正了被动吸烟及胎次等可能的混杂因素后,经Mentcl-Haenszel 法检验,两组间仍有显著差异,X~2-MH 5,865,P<0.05;OR-MH 2.058,95%可信限1.148～3.692,SRR 2.139。但未见有特异畸形出现。
In this study, 682 married women who contacted CS_2 in four chemical fiber factories in Hebei, Henan, Liaoning and Hubei Province were selected as the observation objects. A control group of 745 married women from cotton mills in the same district was used as control group. The history of birth was investigated by a historical prospective method. The number of pregnancies in contact group was 1112 times and that in control group was 1494 times. Results: The incidence of birth defects in offspring was 26.44 ‰, significantly higher than that of the control group (13.07 ‰), RR2.02, 95% confidence interval was 1.13 to 3.60, P <0.025. After adjusting for possible confounding factors such as passive smoking and parity, there was still significant difference between the two groups by Mentcl-Haenszel test, with X ~ 2-MH 5,865, P <0.05; OR-MH 2.058,95% The limits of 1.148 ~ 3.692, SRR 2.139. But no special deformity appeared.