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光动力疗法(PDT)是继手术、放化疗等传统治疗肿瘤手段外的一种新的抗肿瘤模式。PDT机制目前尚不完全清楚,已知其利用肿瘤细胞高摄取光敏剂的特性,使用相应波长的激光照射,使光敏剂产生单线态氧或其他活性氧,通过非细胞凋亡途径或直接高效诱导凋亡或导致肿瘤组织坏死杀死癌细胞。PDT也可损伤肿瘤组织的血管内皮细胞及介导自身免疫系统的激活。
Photodynamic therapy (PDT) is a new anti-tumor model besides the traditional treatment of cancer, such as surgery and radiotherapy and chemotherapy. PDT mechanism is not yet fully understood, it is known that its use of high-sensitivity photosensitizer tumor characteristics, the use of the corresponding wavelength of laser irradiation, the photosensitizer to generate singlet oxygen or other reactive oxygen species, by non-apoptotic pathway or directly and efficiently induced Apoptosis or necrosis of tumor tissue kills cancer cells. PDT can also damage tumor tissue of vascular endothelial cells and mediate the activation of the autoimmune system.