肺癌是当今世界发病率与死亡率位于前列的恶性肿瘤之一。肺癌的发生是一个多步骤,多因素参与的复杂的生物学过程,涉及基因和基因外的多种改变,基因改变是指基因本身结构的异常,方式突变、基因缺失、扩增、重排等;基因外改变即表观遗传学改变。DNA甲基化是最重要的一种表观遗传 Lung cancer is one of the most malignant tumors with morbidity and mortality in the world today. The occurrence of lung cancer is a complex multi-step and multi-factorial biological process that involves many kinds of changes in genes and genes. Gene mutation refers to the abnormality of the gene itself, the mutation of the gene, the deletion of the gene, amplification, rearrangement, etc. ; Epigenetic changes that epigenetic changes. DNA methylation is the most important form of epigenetics