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目的 通过健脾护齿方结合牙周基础治疗对围绝经期妇女慢性牙周炎的疗效及对内分泌的调节作用,观察其治疗慢性牙周炎的临床疗效。方法 将46例患中、重度慢性牙周炎的围绝经期妇女,随机分为两组。实验组予以健脾护齿方结合牙周基础治疗,对照组仅予以牙周基础治疗。疗程6周。对治疗前后患者的牙周探诊出血指数(bleeding on probing,BOP)、牙周探诊深度(peridental pocket depth,PPD)和牙周附着水平(peridental attachment level,PAL),龈沟液中白细胞介素(interleukin,IL)-1β、IL-8以及外周血血清中雌二醇(estradiol,E2)、黄体生成素(luteinizing hormone,LH)和促卵泡刺激素(follicle-stimulating hormone,FSH)进行检测。结果 治疗3个月后实验组龈沟液中IL-1β水平、PPD和PAL较对照组明显下降(P<0.05);LH水平明显上升(P<0.05);但两组病例BOP治疗前后差异无统计学意义(P>0.05)。结论 健脾护齿方结合牙周基础治疗对慢性围绝经期妇女牙周炎患者有较好的治疗效果,同时对内分泌也有调节作用。
Objective To observe the curative effect and endocrine regulation effect of Jianpi Huzhuo combined with periodontal therapy on chronic periodontitis in perimenopausal women and to observe its clinical efficacy in treating chronic periodontitis. Methods 46 cases of perimenopausal women with moderate to severe chronic periodontitis were randomly divided into two groups. In the experimental group, Jianpi Huzhuo combined with periodontal treatment and control group received only periodontal basic treatment. Treatment for 6 weeks. Perioperative bleeding on probing (BOP), peridental pocket depth (PPD), and peridental attachment level (PAL) were measured before and after treatment. Interleukin Interleukin (IL) -1β, IL-8 and serum estradiol (E2), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) . Results The level of IL-1β, PPD and PAL in gingival crevicular fluid of experimental group decreased significantly (P <0.05) and LH level increased significantly (P <0.05) after 3 months of treatment. However, there was no significant difference between the two groups before and after BOP treatment Statistical significance (P> 0.05). Conclusion Jianpi Huzhuo combined with periodontal treatment of chronic perimenopausal women with periodontitis have a better therapeutic effect, while also regulating the role of endocrine.