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目的:探讨谷胱甘肽过氧化物酶(GSH-PX)、脂质过氧化物(LPO)、超氧化物歧化酶(SOD)与妊娠肝内胆汁淤积症(intrahepatic cholestasis of Pregnancy,ICP)的发病关系。方法:采用二硝基苯甲酸直接法、硫代巴比妥酸荧光测定法及速率法测定35例ICP患者和20例正常孕妇及两组孕妇新生儿脐血全血GSH-PX、血浆LPO、SOD水平,同时测定样本肝功能指标(TB IL、TBA)进行相关性分析。结果:ICP组GSH-PX水平较对照组显著降低,差异显著(P<0.01)。ICP组LPO、SOD水平较对照组明显升高,差异性显著(P<0.01)。ICP患者新生儿脐血GSH-PX、LPO、SOD水平明显高于正常对照孕妇脐血水平,差异性显著(P<0.01)。ICP患者GSH-PX、LPO、SOD水平与其TB IL、TBA水平呈正相关(P<0.05或P<0.01)。结论:ICP患者GSH-PX、LPO、SOD含量明显发生异常变化,提示其在ICP发病及病理过程中具有重要作用。
Objective: To investigate the effects of glutathione peroxidase (GSH-PX), lipid peroxides (LPO), superoxide dismutase (SOD) and intrahepatic cholestasis of pregnancy (ICP) The relationship between the disease. Methods: The levels of GSH-PX, GSH-PX, and plasma LPO in neonates with umbilical cord blood from 35 ICP patients and 20 normal pregnant women and two groups of pregnant women were determined by direct method of dinitrobenzoate, thiobarbituric acid fluorimetry and rate assay. SOD levels, while the determination of indicators of liver function (TB IL, TBA) were analyzed. Results: The level of GSH-PX in ICP group was significantly lower than that in control group (P <0.01). The levels of LPO and SOD in ICP group were significantly higher than those in control group (P <0.01). The levels of GSH-PX, LPO and SOD in umbilical cord blood of ICP patients were significantly higher than those of normal pregnant women (P <0.01). The levels of GSH-PX, LPO and SOD in ICP patients were positively correlated with their levels of TB IL and TBA (P <0.05 or P <0.01). CONCLUSION: The abnormal changes of GSH-PX, LPO and SOD in ICP patients are significant, suggesting that they play an important role in the pathogenesis of ICP.