早在16世纪时,阿片制剂就被广泛应用于临床,对镇痛、止咳、止泻和镇静,具有很好的疗效。但脑内有阿片受体的存在却迟至1973年才由 Simon,Snyder,Terenius 三个实验室各自独立地加以证明。阿片受体的存在推动人们的巨大的热情去寻找内源性阿片受体的配基。1975年 Hughes 等报告在脑内发现内源性吗啡样因子,随后许多作者相继报道从体内分离出具有吗啡或阿片样活性的物 As early as the 16th century, opiates were widely used clinically and had good effects on analgesia, cough, diarrhea and sedation. However, the existence of opiate receptors in the brain was not confirmed by independent laboratories of Simon, Snyder and Terenius as late as 1973. The existence of opioid receptors drives people’s great enthusiasm to look for ligands for endogenous opioid receptors. In 1975, Hughes et al reported that endogenous morphine-like factor was found in the brain. Subsequently, many authors subsequently reported that morphine or opioid activity was isolated from the body