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的 :建立高丽参注射液的细菌内毒素检测法。方法 :根据中国药典 2 0 0 0版二部收载的细菌内毒素检查的要求进行实验。结果 :高丽参注射液经稀释后可消除对鲎试剂的干扰 ,用灵敏度为 0 .5EU·ml-1的鲎试剂检测内毒素是有效的 ,并与家兔法的结果一致。结论 :对高丽参注射液可用内毒素检查法替代家兔法的热原检查。
: Establishment of bacterial endotoxin test for ginseng injection. Method : Experiments were conducted according to the requirements of the bacterial endotoxin test contained in the Chinese Pharmacopoeia 2000 edition. Results: Dioscorea extract could be used to eliminate the interference to the limulus reagent. The detection of endotoxin with a limulus reagent with a sensitivity of 0.5u·ml-1 was effective and consistent with the results of the rabbit method. Conclusion : The ginseng injection can be replaced by the pyrogen test of the rabbit method.