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目的分析半量尿石通对含钙尿石形成的影响。方法门诊肾结石患者22例,进行自身对照研究,比较服用半量尿石通1个月前后尿p H值、钙、磷、草酸、尿量、尿酸、酸性黏多糖的变化。结果排出结石7例(31.8%),发生肾绞痛1例,口服扶他林后缓解。均无因不能耐受而中断治疗者,服药期间无明显不良反应发生。钙、磷、草酸、p H值、酸性黏多糖及结石形成概率指数服药后明显改变(P<0.05),尿酸和尿量无明显改变(P>0.05)。结论使用半量尿石通并延长用药时间,对于含钙尿石形成的患病因素有影响,可降低结石形成概率指数。
Objective To analyze the influence of half urolithiasis on the formation of calcium-containing uroliths. Methods A total of 22 outpatients with nephrolithiasis were enrolled in this study. Their self-control study was conducted to compare the changes of urinary pH, calcium, phosphorus, oxalic acid, urine volume, uric acid and acid mucopolysaccharides in patients who took half of uroliths a month ago. Results The stones were discharged in 7 cases (31.8%), renal colic occurred in 1 case, relieved after oral fondaparinux. No interruption of treatment due to unacceptable persons, no significant adverse reactions during the medication occurred. The probability index of calcium, phosphorus, oxalic acid, p H value, acid mucopolysaccharide and stone formation changed significantly after treatment (P <0.05), while there was no significant change in uric acid and urine volume (P> 0.05). Conclusions The use of half urolithiasis and prolonged drug use may have an impact on the causative factors of calcium-containing urolithiasis and reduce the probability of stone formation.