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目的检测子宫内膜息肉(EP)患者雌激素受体(ER)、孕激素受体(PR)的表达,探索EP形成的原因及机制。方法 40例EP患者作为观察组,40例经病理组织学证实为正常子宫内膜者作为对照组,两组均采用免疫组化方法手术中所取组织的ER、PR表达水平,并进行比较。结果两组增殖期与分泌期ER表达组间比较差异均无统计学意义(P>0.05);观察组增殖期与分泌期PR表达[(3.002±0.752)、(2.845±0.658)分]均低于对照组[(3.545±0.523)、(3.485±0.585)分],差异均具有统计学意义(P<0.05)。结论 ER、PR的异常表达与EP形成存在相关性,特别是PR低表达可能参与了EP形成的病理过程。
Objective To detect the expression of estrogen receptor (ER) and progesterone receptor (PR) in patients with endometrial polyps (EP) and explore the mechanism and mechanism of EP formation. Methods Forty patients with EP were selected as observation group and 40 patients with normal endometrium by histopathology as control group. The expression of ER and PR in the tissues taken by immunohistochemistry was compared between two groups. Results There was no significant difference between the two groups in proliferative phase and secretory phase ER expression (P> 0.05). The expression of PR in proliferative phase and secretory phase in observation group [(3.002 ± 0.752), (2.845 ± 0.658) In the control group [(3.545 ± 0.523), (3.485 ± 0.585) points], the differences were statistically significant (P <0.05). Conclusion The abnormal expressions of ER and PR are correlated with the formation of EP, especially the low expression of PR may be involved in the pathological process of EP formation.