一般认为,无论是乳腺癌的起源,还是在乳腺癌的播散方面,基因的改变都是重要的。在乳腺肿瘤,7号染色体上基因的重新排列是常见的。作者使用c-ment原癌基因探查染色体7q31的序列结果,对患原发性乳腺癌的245例患者的肿瘤和血液白细胞的DNA标本进行分析,采用Pmet H多态性探针,结果,在杂合子的124例患者中,等位基因缺失率高(占40.5%)。这种基因的变化与标准的预后征象,如肿瘤体积大小、组织病理学分级及淋巴结转移或类固醇受体状态没有明显的相关。然而,手术后无转移的存活期 It is generally believed that genetic changes are important both in the origin of breast cancer and in the dissemination of breast cancer. In breast tumors, the rearrangement of genes on chromosome 7 is common. The authors used c-ment proto-oncogene to probe the sequence of chromosome 7q31 and analyzed the DNA of 245 patients with primary breast cancer and blood leukocytes using Pmet H polymorphism probes. Among 124 patients with zygosity, the allele deletion rate was high (40.5%). This gene change was not significantly associated with standard prognostic signs such as tumor size, histopathological grade, and lymph node metastasis or steroid receptor status. However, no metastasis survival after surgery