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目的：探讨血浆内皮素（ＥＴ）和降钙素基因相关肽（ＣＧＲＰ）在实验性脑出血大鼠急性期中的变化规律，初步分析其在脑出血急性期中的病理生理意义。方法：用Ｎａｔｈ 法复制脑出血大鼠模型，放射免疫法动态测定急性期血浆ＥＴ及ＣＧＲＰ含量，电镜下观察脑组织超微结构变化。结果：实验组血浆ＥＴ 含量在各观察点均明显高于对照组（４ 小时Ｐ＜ ０．０５，１２ 小时与７ 日Ｐ均＜ ０．０１，２４ 小时与７２ 小时Ｐ均＜ ０．００１），７ 日时间点实验组与正常组比较差异非常显著（Ｐ＜ ０．０１）。实验组血浆ＣＧＲＰ含量在各时间点亦明显高于对照组（４ 小时及７ 日Ｐ 均＜ ０．０５，１２、２４ 和７２ 小时Ｐ均＜ ０．０１），７ 日时间点与正常组比较有显著性差异（Ｐ＜ ０．０５）。结论：血浆ＥＴ 及ＣＧＲＰ在脑出血急性期均升高，其变化规律基本一致，与脑损伤程度呈正相关，提示二者对脑出血急性期的病理演变过程有重要意义
Objective: To investigate the changes of plasma endothelin (ET) and calcitonin gene related peptide (CGRP) during the acute phase of experimental intracerebral hemorrhage in rats, and to analyze the pathophysiological significance of ET and CGRP in acute phase of cerebral hemorrhage. Methods: Rat models of intracerebral hemorrhage were reproduced by Nath method. The levels of plasma ET and CGRP in acute phase were determined by radioimmunoassay. The ultrastructural changes of brain tissue were observed under electron microscope. Results: The content of plasma ET in the experimental group was significantly higher than that in the control group (P <0.05 at 4 hours, P <0.01 at 12 hours and 7 days, P <0.001 at 24 hours and 72 hours) There was significant difference between the experimental group and the normal group on the 7th day (P <0.01). The levels of plasma CGRP in the experimental group were also significantly higher than those in the control group at each time point (P <0.05 at 4, 7 and 7 days, P <0.01, P <0.01 at 72, 24 and 72 hours, respectively) There was significant difference (P <0.05). Conclusion: The plasma levels of ET and CGRP are both increased in acute phase of cerebral hemorrhage. The changes of plasma ET and CGRP are basically the same and have a positive correlation with the degree of brain injury, suggesting that both of them have important significance in the pathological process of acute cerebral hemorrhage