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麻醉兔结扎冠状动脉造成急性心肌梗塞模型。实验动物分成两组。对照组,结扎左冠脉前降支的第一分支;改进组,于左冠脉前降支第一分支下及左室支下降段1/2处结扎冠脉。动态观察并记录体表心电图变化。结果改进组与对照组各时间的△ST及Σ△ST段相比均有显著性差异(P<0.05和P<0.01,n=9)。将存活6h的兔处死并取心室作N-BT大体染色,计算梗塞区占心室重的百分比以判断梗塞范围。结果表明,改进组心室梗塞平均百分比为24.7%,对照组为6.7%。提示:改进的急性心肌梗塞模型,不仅避免了只结扎冠脉前降支后代偿性侧枝循环的迅速建立给实验带来的影响;还避免了高位结扎冠脉前降支造成血压迅速下降甚至死亡的危险,是一种有参考价值的方法。
Anesthetic rabbit ligation of the coronary artery caused by acute myocardial infarction model. Experimental animals were divided into two groups. In the control group, the first branch of left anterior descending artery was ligated. In the improved group, the coronary artery was ligated under the first branch of left anterior descending artery and in the descending segment of left ventricular branch. Dynamically observe and record surface ECG changes. Results There were significant differences between △ ST and ΣΔ ST in the improved group and the control group at each time point (P <0.05 and P <0.01, n = 9). The rabbits surviving 6h were sacrificed and the ventricle was taken for general staining of N-BT, and the percentage of infarction area accounting for ventricular weight was calculated to determine the infarct size. The results showed that in the improved group, the average percentage of ventricular infarction was 24.7% and that of the control group was 6.7%. Hint: The improved model of acute myocardial infarction not only avoids the rapid establishment of compensatory collateral circulation after ligation of the anterior descending coronary artery, but also prevents the rapid descending of blood pressure caused by the anterior descending coronary artery ligation The danger of death is a valuable reference.