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目的 :建立新的大鼠慢性萎缩性胃炎 (CAG)证病结合模型 ,并观察其实验 35周的胃粘膜病理改变。方法 :雌性大鼠 ,分为对照组、CAG组、脾虚CAG组、肝郁CAG组、肾虚CAG组。CAG模型采用脱氧胆酸钠和阿斯匹林水溶液交替饮用加免疫损伤法 ,脾虚证模型采用耗气破气加饥饱失常法 ,肝郁证模型采用夹尾加肾上腺素注射法 ,肾虚证模型采用MTU溶液饮用法。总造模期 35周。造模结束后光镜观察胃粘膜病理改变。结果 :CAG模型各组胃粘膜有明显的萎缩性改变 ,而炎证和纤维化程度相对较轻。组间的差异主要表现在胃粘膜萎缩的程度上 ,以脾虚CAG组和肾虚CAG组最为严重。肝郁CAG组胃粘膜萎缩程度较轻。结论 :本实验在完善CAG证病结合模型方面作了尝试 ,并以之初步观察了证、病和证病结合在胃粘膜病理上的反映。
Objective: To establish a new model of chronic atrophic gastritis (CAG) syndrome in rats and to observe the pathological changes of gastric mucosa 35 weeks after the experiment. Methods: Female rats were divided into control group, CAG group, spleen deficiency CAG group, liver depression CAG group and kidney deficiency CAG group. CAG model using sodium deoxycholate and aspirin aqueous solution alternately drinking plus immune injury method, spleen deficiency model using gas broken gas and hungry method, liver stagnation model with clip tail plus adrenaline injection, kidney deficiency syndrome model Using MTU solution drinking method. The total modeling period of 35 weeks. After modeling, observe the pathological changes of gastric mucosa by light microscope. Results: The gastric mucosa of CAG model showed obvious atrophic changes, while the degree of inflammation and fibrosis was relatively low. Differences between groups mainly manifested in the degree of gastric mucosal atrophy, spleen deficiency CAG group and kidney deficiency CAG group the most serious. Liver depression CAG group gastric mucosal atrophy lighter. Conclusion: This experiment attempts to perfect the model of CAG syndrome and disease, and initially observed the combination of syndrome, disease and syndrome in the gastric mucosal pathology.