论文部分内容阅读
用小鼠可移植性组织细胞型淋巴瘤ＬⅡ接种于近交系６１５小鼠右后爪垫皮下，按宿主荷瘤时间以及肿瘤生长发展的不同阶段分期分批取血，检测荷瘤小鼠ＰＢＣ－Ｃ＿（３ｂ）ＲＲ和ＲＢＣ－ＩＣＲ，结合组织学观察，将肿瘤生长发展过程分为潜伏期，侵袭早、中、晚期，转移早、中、晚期等７个时期。观察ＲＢＣ－Ｃ＿（３ｂ）ＲＲ明显低于正常，并随肿瘤的发展呈下降趋势；而ＲＢＣ－ＩＣＲ高于正常，在肿瘤侵袭中期急骤增高，以后稳定在较高水平。提示：肿瘤的侵袭转移与宿主红细胞免疫功能下降有一定关系。实验组与正常组相比Ｐ＜０．０１＋实验组与瘤组相比Ｐ＜０．０１表２ 红细胞免疫复合物花环率（ＲＢＣ－ＩＣＲ）（Ｘ±ＳＤ）实验组与正常组相比Ｐ＜０．０１＋＋实验组与死瘤组相比Ｐ＜０．０１从表中可见，肿瘤移植后第１天为潜伏期，第３天为侵袭早期，第５天为侵袭中期，第１０天为侵袭晚期，此期开始出现引流淋巴结的肿瘤转移，故又为转移早期。第２０天非引流淋巴结表现转移为转移中期，第３０天出现肺转移为转移晚期。从表中可见，肿瘤移植后第１天，ＲＢＣ－Ｃ３ｂＲＲ开始就低于正常，并随着肿瘤的发展而逐渐降低，阴性对照组则与正常组无显著性差异；ＲＢＣ－ＩＣＲ在肿瘤移植后第５天开?
The mice were transplanted with mouse transplantable histiocytic lymphoma LII and inoculated subcutaneously in the right hind paw pad of 615 inbred mice. The blood was collected in batches according to the time of the host tumor and the different stages of tumor growth and development. The tumor-bearing mice PBC were detected. -C_ (3b) RR and RBC-ICR, combined with histological observation, divided the development process of tumor into latent period, invasion of early, middle and late stages, metastasis early, middle and late stages. Observed RBC-C_(3b) RR was significantly lower than normal, and with the development of the tumor showed a downward trend; and RBC-ICR was higher than normal, rapid increase in the mid-stage tumor invasion, later stabilized at a higher level. Tip: The invasion and metastasis of tumors have a certain relationship with the decline of host red blood cell immune function. P<0.01 in experimental group compared with normal group P<0.01 in experimental group compared with tumor group Table 2 RBC-ICR (X±SD) rosette rate in experimental group compared with normal group P <0.01++ experimental group compared with the death group P<0.01 From the table, the first day after tumor transplantation is the incubation period, the first day of the invasion is the third day, the middle of the invasion of the fifth day, the first 10 days of invasion In the late stage, lymph node metastasis began to occur in this period, so it was early metastasis. On the 20th day, the non-draining lymph node metastasized to the metaphase metastasis, and on the 30th day, the lung metastasis was late metastasis. It can be seen from the table that RBC-C3bRR starts to be lower than normal on the first day after tumor transplantation, and gradually decreases with the development of the tumor. There is no significant difference between the negative control group and the normal group; RBC-ICR is after tumor transplantation On the 5th day?