海南金不换属防已科植物,海南民间用来治疗胃痛、神经痛、毒蛇咬伤等。去年五月份曾用其块根的脂溶性生物碱进行了肌松试验,其注射剂应用临床十余例,证明有一定的肌松作用。但由于临床剂量较大(1.0毫升/公斤),为了减少用量,我们将总碱进行了初步分离,并将制剂工艺作了改进。现将初步的实验研究总结如下。 Hainan Gold is not a sub-genus of plants, Hainan folk used to treat stomach pain, neuralgia, snake bites and so on. In May of last year, muscle relaxant tests were conducted using fat-soluble alkaloids in their roots, and more than ten cases of injections were used clinically to prove that they have a certain degree of muscle relaxation. However, due to the large clinical dose (1.0 ml/kg), we have conducted a preliminary separation of total alkaloids in order to reduce the dosage and improved the formulation process. The preliminary experimental study is summarized below.