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GBP是一种类似GABA的氨基酸,具有新的作用机制,对全身强直一阵挛性发作和部分性发作特别有效,其药代动力学较简单,和其他AEDs之间无相互作用,认为是一种较理想的附加AEDs。本文对GBP的理化特性、药代动力学、作用机制临床效用及副反应作一综述。
GBP is a GABA-like amino acid with a novel mechanism of action that is particularly effective for generalized tonic-clonic and partial seizures. Its pharmacokinetics is relatively simple and does not interact with other AEDs and is considered as a More desirable additional AEDs. This article reviews the physico-chemical properties, pharmacokinetics, clinical utility and side effects of GBP.