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目的 :评价国产聚乙烯醇 (PVA)的动脉栓塞效果。方法 :杂种犬 15只 ,选择国产PVA和进口PVA分别栓塞左、右侧肾上极动脉 ,PVA的规格为 2 5 5～ 35 5 μm。 3只犬栓塞后立即处死 ,剩下的犬 1周、4周、12周、2 6周分别处死 3只。处死前进行双侧肾动脉造影 ,然后把双侧肾脏进行组织病理学检查。结果 :国产PVA和进口PVA均能阻塞靶血管和导致双肾上极坏死 ,两种栓塞材料所栓塞的血管在随访中都能再通 ,动脉内的栓子均由PVA和血栓组成 ,国产PVA与进口PVA在其血管周围具有相同的炎症反应 (P >0 .0 5 ) ,国产PVA对动脉壁的破坏 0周时较进口PVA严重 (P <0 .0 5 ) ,1周、4周、12周、2 6周时与进口PVA相同 (P >0 .0 5 )。结论 :国产PVA与进口PVA具有相似的栓塞效果 ,适合作血管栓塞剂。
Objective: To evaluate the effect of domestic polyvinyl alcohol (PVA) on arterial embolism. Methods: Fifteen hybrid dogs were selected. The domestic and imported PVA were selected to embolize the left and right superior superficial arteries, respectively. The specifications of PVA ranged from 25 5 to 35 5 μm. Three dogs were sacrificed immediately after embolization, and the remaining dogs were sacrificed for 1 week, 4 weeks, 12 weeks and 26 weeks respectively. Before death, bilateral renal artery angiography was performed, and bilateral renal histopathology was performed. Results: Domestic PVA and imported PVA could both occlude the target vessel and cause superficial necrosis of both kidneys. The blood vessels embolized by both embolic materials could be recanalized at follow-up. The intra-arterial emboli were composed of PVA and thrombus. The domestic PVA (P> 0.05). Compared with the imported PVA, the inflammatory reaction around the blood vessels in the same PVA (P> 0.05) 12 weeks and 26 weeks with imported PVA (P> 0.05). Conclusion: Domestic PVA and imported PVA have similar embolization effect, which is suitable as a vascular embolic agent.