1988及1990年在滇南恶性疟流行区用体外微量法测得恶性疟原虫对氯喹、咯萘啶、青蒿琥酯及哌喹的抗性率分别为98.7％(75/76)、27.6％(16/58)、13.8％(9/65)及97.7％(43/44);半数抑制量(ID_(50))分别为125.0、19.0、4.7及243.3nmol/L,抗氯喹恶性疟原虫对哌喹有明显的交叉抗性;对咯萘啶及青蒿琥酯则未见明显的交叉抗性。抗青蒿琥酯恶性疟原虫对以上3种药均有一定程度的交叉抗性。抗咯萘啶恶性疟原虫对青蒿琥酯无交叉抗性,而对氯喹及哌喹有一定程度的交叉抗性。 The resistance rates of Plasmodium falciparum to chloroquine, pyronaridine, artesunate and piperacillin were 98.7% (75/76) and 27.6% (respectively) in 1988 and 1990, respectively. (16/58), 13.8% (9/65) and 97.7% (43/44), respectively. The median inhibitory concentrations (ID_ (50)) were 125.0, 19.0, 4.7 and 243.3 nmol / Piperacillin has obvious cross-resistance; no obvious cross-resistance to pyronaridine and artesunate. Anti-artesunate falciparum Plasmodium have a certain degree of cross-resistance to the above three drugs. Resistant to naphthyridine falciparum did not cross-resistant to artesunate, but had some degree of cross-resistance to chloroquine and piperaquine.