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肝癌的发生同其他人类肿瘤一样,都是由表观遗传学异常和基因改变共同引起,DNA甲基化是表观遗传学上研究最为深入的一种机制。在肝癌的发生发展过程中,抑癌基因等肿瘤相关基因的高甲基化和整个基因组水平的低甲基化起着重要作用,肝癌的甲基化研究对肝癌的早期诊断和病情预后的监测及其防治具有重要意义。在此对肝癌DNA甲基化特征及其临床意义进行阐述。
The occurrence of liver cancer, like other human tumors, is caused by both epigenetic abnormalities and genetic changes. DNA methylation is one of the most studied epigenetic mechanisms. In the development and progression of hepatocarcinoma, hypermethylation of tumor-related genes such as tumor suppressor genes and hypomethylation at the whole genome play an important role. Methylation analysis of hepatocellular carcinoma monitors the early diagnosis and prognosis of hepatocellular carcinoma and its prognosis Prevention is of great importance. This article describes the characteristics of DNA methylation in hepatocellular carcinoma and its clinical significance.