论文部分内容阅读
目的：通过对非超重和超重肥胖的正常人、糖尿病血缘亲属、ＩＧＴ及２型糖尿病人空腹的胰岛素（Ⅰ）、Ｃ肽（Ｃ）和前胰岛素（ＰＩ）测定，以了解２型糖尿病人的基础β细胞功能改变。方法：利用ＲＩＡ。结果：各超重肥胖组（Ⅱ、Ⅳ、Ⅵ、Ⅷ）的Ｉ、Ｃ和ＰＩ水平均高于相应非超重组（Ⅰ、Ⅲ、Ⅴ、Ⅶ）（Ｐ＜０．０５）。无论超重肥胖抑非超重组，即正常人→糖尿病亲属→ＩＧＴ→糖尿病组的ＰＩ水平有逐渐上升趋势（Ｐ＜０．０１）。糖尿病两组（Ⅶ、Ⅷ）的Ｉ和Ｃ无继续上升，而ＰＩ仍继续上升（Ｐ＜０．０１）。糖尿病两组的ＰＩ／Ｉ（％）比值高于正常人（Ⅰ、Ⅱ）组（Ｐ＜０．０５）。结论：超重肥胖对胰岛β细胞功能确有影响，胰岛β细胞功能改变在ＩＧＴ阶段已非常明显，在糖尿病阶级更加突出，并出现“不成比例”的ＰＩ升高现象。
OBJECTIVE: To investigate the fasting insulin (I), C peptide (C) and proinsulin (PI) in non-overweight and overweight obese healthy people, relatives of blood relatives, IGT and type 2 diabetes patients Basal β-cell function changes. Methods: Using RIA. Results: The levels of I, C and PI in overweight and obesity group (Ⅱ, Ⅳ, Ⅵ and Ⅷ) were higher than those in the corresponding non - overweight group (Ⅰ, Ⅲ, Ⅴ and Ⅶ) (P <0.05). No matter overweight or obese, the level of PI in non-overweight group (normal group, diabetic relatives, IGT group and diabetic group) increased gradually (P <0.01). I and C in the two groups (Ⅶ, Ⅷ) of diabetes did not continue to rise, but PI continued to rise (P <0.01). The ratio of PI / I (%) in diabetes was higher than that in normal people (Ⅰ, Ⅱ) (P <0.05). CONCLUSIONS: Overweight and obesity has a definite effect on pancreatic β-cell function. The changes of pancreatic β-cell function are very obvious during the IGT stage and more prominent in the diabetic stage with “disproportionate” PI increase.