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目的分析该院大肠埃希菌感染分布及耐药性,指导临床合理选用抗菌药物,预防院内感染。方法采用全自动微生物分析仪对该院1 588株临床分离的大肠埃希菌进行鉴定及药物敏感试验,对病原菌分布及耐药情况用WHONET5.5进行统计分析。结果大肠埃希菌占分离菌的57.5%,主要分离自尿液(42.6%),大肠埃希菌对亚胺培南、美罗培南,厄他培南的敏感性最高分别为99.6%、99.5%、99%,对氨苄西林的耐药性最高87.3%。产超广谱(ESBLs)菌株的检出率51.8%,其耐药率增高。结论该院大肠埃希菌感染主要为泌尿系感染,耐药情况严重,产ESBLS大肠埃希菌耐药性增高,应规范合理使用抗菌药物。
Objective To analyze the distribution and drug resistance of Escherichia coli in this hospital and to guide the rational use of antibiotics in clinical trials to prevent nosocomial infections. Methods A total of 1 588 clinical isolates of Escherichia coli from the hospital were identified and drug sensitive tests by automatic microbiological analyzer. The distribution and drug resistance of pathogens were analyzed by WHONET5.5. Results Escherichia coli accounted for 57.5% of the isolates, mainly from urine (42.6%). The highest sensitivity of Escherichia coli to imipenem, meropenem and ertapenem was 99.6% and 99.5% , 99%, the highest resistance to ampicillin 87.3%. The detection rate of producing extended-spectrum (ESBLs) strains was 51.8%, and the rate of resistance increased. Conclusions The Escherichia coli infection in this hospital is mainly urinary tract infection. The drug resistance is serious. Escherichia coli producing ESBLS is more resistant. Antibacterial drugs should be standardized and reasonable.