论文部分内容阅读
自1957年Isaacs等发现干扰素后,相继报导除病毒外,还有许多物质可诱生干扰素,但根据诱生剂及其作用的靶细胞不同,所产生的干扰素在性质上也有所不同。特别是T细胞有丝分裂素,如植物血凝素(PHA),刀豆素A(ConA),以及某些特异性的病毒和非病毒抗原刺激T淋巴细胞后所产生的干扰素,在理化和生物学性质上与经典干扰素有较大不同。过去对这类干扰素所知甚少,近年来发现,它的细胞调节作用比经典干扰素强的多,可能对抗肿瘤和抗病毒感染具有重要作用,因而逐渐受到各国学者重视。本文就近年来对这一类型干扰素的研究进展作一简单介绍。
Since the discovery of interferon by Isaacs et al. In 1957, many other substances have been reported to cause interferon in addition to viruses. However, the interferons produced are different in nature depending on the target cells of the inducer and its effect . Especially T-cell mitogen such as phytohemagglutinin (PHA), concanavalin A (ConA), as well as some specific viral and non-viral antigens stimulate the T lymphocytes produced after interferon, in the physical and chemical and biological The nature of the study is quite different from the classic interferon. In the past, little was known about such interferons. In recent years, it has found that its cell-regulating effect is much stronger than that of classical interferons and may play an important role in anti-tumor and antiviral infection. Therefore, it has drawn increasing attention from scholars in various countries. This article in recent years on the research progress of this type of interferon make a brief introduction.