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目的:探索SD大鼠腺性膀胱炎尿流动力学检查方法。方法:将50只SD大鼠分成3组:模型组采用DH5α大肠杆菌溶液,隔两日灌注雌性SD大鼠膀胱诱导产生腺性膀胱炎动物模型;盐水对照组采用生理盐水每隔两日膀胱灌注,共持续45天;空白组不采取任何干预措施,同条件饲养。45天后行尿流动力学检查及病理检测。结果:尿动力学检查提示模型组大鼠储尿期膀胱逼尿肌不稳定发生率与对照组、空白组相比差异有统计学意义(P<0.001)。结论:确立了腺性膀胱炎的动物模型尿流动力学检查方法。
Objective: To explore the urodynamics of SD rat glandular cystitis. Methods: Fifty SD rats were divided into three groups: model group, DH5α E. coli solution was used to induce glandular cystitis animal model by intravesical instillation of female SD rats on the second day; saline control group was injected with saline every two days For a total of 45 days; the blank group did not take any interventions, keeping the same conditions. Urine flow cytometry and pathology were performed 45 days later. Results: Urodynamic examination showed that the incidence of bladder detrusor instability in rats during storage was significantly lower than that in control and blank control groups (P <0.001). Conclusion: The animal model of urinary cystitis was established.