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目的研究实体肿瘤组织间质各向异性传导系数对流体流动的影响。方法用图像处理方法建立具有实体肿瘤微血管形态和分布特征的二维微血管网络模型,应用边界元方法数值计算多连通区域内组织液的流动及水力传导系数变化的影响。结果横向与纵向间质水力传导系数的不同,对整个肿瘤内组织间质压强的分布有明显的影响;不同函数形式分布的水力传导系数,影响肿瘤局部区域内间质流体压强的分布。结论各向异性水力传导系数对实体肿瘤组织间质压强有明显影响,与传导系数变化的范围和肿瘤内微血管网络的形态有关。
Objective To study the effect of the interstitial anisotropy of solid tumor tissue on fluid flow. Methods A two-dimensional capillary network model with solid tumor microvessel morphology and distribution features was established by image processing. The boundary element method was used to numerically calculate the influence of tissue fluid flow and hydraulic conductivity on the multi-connected area. Results The difference of hydraulic conductivity between horizontal and vertical interstitial obviously affected the distribution of interstitial pressure in the whole tumor. The hydraulic conductivity of different functional distribution affected the distribution of interstitial fluid pressure in the local area of tumor. Conclusion The anisotropic hydraulic conductivity has a significant effect on the interstitial pressure of solid tumor tissue, which is related to the range of the change of conductivity and the morphology of the intracranial microvascular network.