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幽门螺杆菌(Helicobacterpylori,Hp)的重要毒力基因cagA具有高度保守的5′区和可变的3′区,3′区中重复序列类型和数量的差异造成了cagA基因产物(CagA蛋白)在分子大小上的不同。cagA基因 CagA蛋白的结构差异可能最终影响Hp感染的临床结局。亚洲Hp菌株和非亚洲菌株cagA基因3′区
The major virulence gene cagA of Helicobacter pylori (Hp) has a highly conserved 5 ’region and a variable 3’ region. The difference in the types and amounts of repetitive sequences in the 3 ’region results in the cagA gene product (CagA protein) Different molecular size. Structural differences in the cagA protein CagA protein may ultimately affect the clinical outcome of Hp infection. Asian Hp strain and non-Asian strain cagA gene 3 ’region