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目的探讨大环内酯类抗生素在临床上的不良反应,为此类药物的合理使用提供参考依据。方法随机抽取72例我院在2012年1月至2014年12月发生大环内酯类抗生素不良反应的患者作为研究对象,对其临床资料和不良反应的类型进行回顾性分析。结果经分析,胃肠系统反应、肝脏损伤、皮肤性过敏反应、过敏性休克和血栓性静脉炎是服用大环内酯类抗生素后主要的不良反应类型,发生率分别为27.78%、5.56%、50%、11.11%和5.56%。结论在各类大环内酯类抗生素不良反应中,胃肠系统反应和皮肤性过敏的发生率最高,且新品种药物的不良反应发生率低于老品种。
Objective To investigate the clinical adverse reactions of macrolide antibiotics and provide reference for rational use of these drugs. Methods A total of 72 patients with adverse reactions of macrolide antibiotics in our hospital from January 2012 to December 2014 were randomly selected for the study. The clinical data and the types of adverse reactions were retrospectively analyzed. Results The gastrointestinal system reaction, liver injury, cutaneous anaphylaxis, anaphylactic shock and thrombophlebitis were the main adverse reactions after taking macrolide antibiotics, the incidence rates were 27.78%, 5.56% 50%, 11.11% and 5.56%. Conclusions Among the adverse reactions of macrolide antibiotics, the incidence of gastrointestinal reactions and skin allergies is the highest, and the incidence of adverse reactions of new varieties of drugs is lower than that of old varieties.