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[目的]探讨TNF-α含量的变化与慢性牙周炎病情的关系以及牙周基础治疗对TNF-α含量变化的影响。[方法]选取40例慢性牙周炎为研究对象,采用ELISA法在治疗前后分别测定血清和患牙龈沟液TNF-α含量并分析其与牙周临床指标的相关性。[结果]治疗前后比较,PLI、PD、AL均有明显改善(P﹤0.05),SBI及龈沟液中TNF-α含量均有非常明显改善(P﹤0.01),但血清TNF-α变化不明显(P﹥0.05)。治疗前血清和龈沟液中TNF-α与PLI、PD、AL、SBI均呈显著性正相关(P﹤0.05);治疗后血清TNF-α与PLI、PD、AL、SBI均无显著相关性(P﹥0.05),而龈沟液中TNF-α与PLI、PD、AL、SBI均呈显著或非常显著性正相关(P﹤0.05或﹤0.01)。[结论]TNF-α含量的变化可以反映慢性牙周炎的病情进展和治疗效果,而以龈沟液中TNF-α含量的变化最为敏感;对慢性牙周炎施以牙周基础治疗,对龈沟液中TNF-α含量也产生明显影响。
[Objective] To investigate the relationship between the changes of TNF-α content and chronic periodontitis and the effect of periodontal treatment on the content of TNF-α. [Methods] Forty chronic chronic periodontitis patients were selected as study objects. The levels of TNF-α in serum and gingival crevicular fluid were measured by ELISA before and after treatment. The correlations were analyzed with clinical data of periodontal disease. [Results] The levels of PLI, PD and AL in both groups were significantly improved before and after treatment (P <0.05), while the levels of TNF-α in SBI and gingival crevicular fluid were significantly improved (P <0.01) Obviously (P> 0.05). There was a significant positive correlation between TNF-α and PLI, PD, AL and SBI in serum and gingival crevicular fluid before treatment (P <0.05). There was no significant correlation between TNF-α and PLI, PD, AL and SBI (P> 0.05). There was a significant or significant positive correlation between TNF-α and PLI, PD, AL and SBI in GCF (P <0.05 or <0.01). [Conclusion] The change of TNF-α content can reflect the progression of disease and treatment effect of chronic periodontitis, but the change of TNF-α content in gingival crevicular fluid is the most sensitive. Periodontal treatment of chronic periodontitis Gingival crevicular fluid TNF-α content also had a significant impact.