自身免疫性疾病的T淋巴细胞 Paul Ehrlich采用“体液自身毒”一语来描述机体由于免疫系统异常,导致自身结构的识别和破坏的病理。多年来,人们已经观察到能与各种组织抗原的不同决定簇产生特异性结合的体液性抗体。们是,近年来大量证据表明,许多自身攻击性疾病最初可能并不是由体液抗体引起,而是由自身免疫性T淋巴细胞所致。诱导性自身免疫的动物模型,是支持免疫性自身攻击的细胞机制的最早证据。实验性自 T-lymphocytes from autoimmune diseases Paul Ehrlich uses the term “humoral self-toxicity” to describe the pathology of the body’s recognition and destruction of its own structure as a result of an abnormal immune system. For many years, humoral antibodies that specifically bound to different determinants of various tissue antigens have been observed. They are, in recent years, a large body of evidence that many of the self-aggressive diseases may not have been caused by humoral antibodies initially, but by autoimmune T-lymphocytes. An animal model of induced autoimmunity is the earliest evidence that supports cellular mechanisms of autoimmune self-challenge. Experimental self