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目的:评价阿莫西林和奥美拉唑与甲硝唑联用对幽门螺杆菌感染胃溃疡患者血清炎症因子与胃泌素指标值的影响。方法:选取医院2013年10月—2016年5月期间收治的幽门螺杆菌(Hp)感染胃溃疡患者105例,将其分为A组54例和B组51例;A组患者给予阿莫西林、奥美拉唑与甲硝唑治疗,B组患者给予奥美拉唑治疗,比较治疗前后两组患者的血清炎症因子与胃泌素指标值的变化情况。结果:治疗前两组患者血清炎症因子与胃泌素指标值经间比较其差异无统计学意义(P>0.05),治疗后两组患者的血清炎症因子与胃泌素指标值均明显优于治疗前(P<0.05);A组患者用药后C反应蛋白(CRP)、白细胞介素-6(IL-6)和白细胞介素-1(IL-1)等血清炎症因子值均低于B组,患者的胃动素(MTL)值明显高于B组(P<0.05),胆囊收缩素(CCK)和胃泌素(GAS)等胃泌素相关指标值均明显低于B组(P<0.05)。结论:阿莫西林与甲硝唑能显著改善幽门螺杆菌感染胃溃疡患者的血清炎症因子与胃泌素相关指标值。
Objective: To evaluate the effect of combination of amoxicillin and omeprazole with metronidazole on serum inflammatory factors and gastrin index in patients with gastric ulcer induced by Helicobacter pylori infection. Methods: A total of 105 gastric ulcer patients with Helicobacter pylori (Hp) in hospital from October 2013 to May 2016 were divided into group A (54 cases) and group B (51 cases). Patients in group A were given amoxicillin , Omeprazole and metronidazole treatment, patients in group B were treated with omeprazole, before and after treatment in patients with serum inflammatory cytokines and gas index changes. Results: Before treatment, there was no significant difference between serum inflammatory factor and gastrin index (P> 0.05), serum inflammatory factor and gastrin index of the two groups were significantly better than those before treatment The serum levels of C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin-1 (IL-1) in group A were lower than those before treatment (P <0.05). Gastrin related indexes such as cholecystokinin (CCK) and gastrin (GAS) were significantly lower than those in group B (P <0.05) <0.05). Conclusion: Amoxicillin and metronidazole can significantly improve serum Helicobacter pylori infection in patients with gastric ulcer serum gastrin-related index values.