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目的探讨经皮氩氦刀治疗晚期非小细胞肺癌合并COPD患者的近期及远期疗效。方法对65例EGFR野生型、ⅢB、Ⅳ期非小细胞肺癌合并慢性阻塞性肺疾病的肺癌患者,放疗存在一定的风险,在全身化疗的基础上结合经皮氩氦刀局部治疗,观察其近期及远期效果和不良反应。结果 65例患者经过全身及局部联合治疗后,近期有效率达到了43.08%,疾病控制率(DCR)为89.23%,所有患者的不良反应均为1~2级,经处理后都能完成整个治疗过程。治疗后中位PFS为6个月,中位OS为13个月。结论对EGFR野生型晚期非小细胞肺癌合并慢性阻塞性肺疾病的肺癌患者,在全身化疗的基础上结合经皮氩氦刀局部治疗可以进一步提高治疗效果。
Objective To investigate the short-term and long-term effects of percutaneous argon-helium knife in the treatment of advanced non-small cell lung cancer with COPD. Methods 65 cases of EGFR wild type, Ⅲ B, Ⅳ non-small cell lung cancer with chronic obstructive pulmonary disease in patients with lung cancer, there is a certain risk of radiotherapy, combined with systemic chemotherapy on the basis of local treatment of percutaneous argon helium knife to observe the recent And long-term effects and adverse reactions. Results 65 cases of patients after systemic and local combination therapy, the recent effective rate reached 43.08%, disease control rate (DCR) was 89.23%, all patients with adverse reactions were 1 to 2, after treatment can be completed the entire treatment process. Median PFS after treatment was 6 months and median OS was 13 months. Conclusion In patients with lung cancer with EGFR wild-type NSCLC and chronic obstructive pulmonary disease, the combination of systemic chemotherapy and topical argon-helium cryotherapy can further improve the therapeutic effect.