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为了探讨20项新生儿行为神经测定(NBNA)在预报新生儿胆红素脑病中的意义,将20项NBNA应用于67例高胆红素血症患儿(足月儿),其中33例同时测脑干听觉诱发电位(ABR)。结果:(1)血清胆红素水平愈高,NBNA评分<35分者愈多;ABR异常愈严重,NBNA评分<35分者也愈多。(2)黄疸消退后,67例患儿的NBNA评分比黄疸高峰期普遍提高,差异有非常显著意义(P<0.01)。(3)黄疸高峰期10例NBNA<35分者,黄疸消退后仍有5例NBNA<35分。NBNA≥35分者,黄疸消退后NBNA均≥37分。提示:NBNA能预报新生儿胆红素脑病,并能指导临床治疗,对NBNA<35分的患儿应采取积极有效的措施,甚至换血治疗,以防止核黄疸的发生。
To investigate the significance of 20 neonatal behavioral neurological tests (NBNA) in the prediction of neonatal bilirubin encephalopathy, 20 NBNAs were applied to 67 children with hyperbilirubinemia (term infants), of which 33 Brainstem auditory evoked potentials (ABR) were measured. Results: (1) The higher the level of serum bilirubin, the more NBNA score <35; the more serious abnormal ABR, the more NBNA score <35. (2) After jaundice subsided, the NBNA score of 67 children was generally higher than the peak of jaundice, the difference was significant (P <0.01). (3) In the peak of jaundice, 10 cases had NBNA <35 points, and 5 cases still had NBNA <35 points after jaundice subsided. NBNA ≥ 35 points, NBNA were ≥ 37 points after jaundice subsided. Tip: NBNA can predict neonatal bilirubin encephalopathy, and can guide the clinical treatment of NBNA <35 points in children should take positive and effective measures, and even exchange transfusion to prevent the occurrence of nuclear jaundice.