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目的分析成人单剂乙型肝炎疫苗(Hep B)免疫应答效果及其影响因素。方法选择16~54岁成人1 678人进行免疫前血清HBs Ag、抗-HBs和抗-HBc定量检测,其中3项指标均阴性的980人给予60μg Hep B1剂,并在免疫后1个月检测抗-HBs,分析抗-HBs阳转率和滴度水平。结果 980人免疫后1个月抗-HBs阳转率为19.39%,几何平均滴度为3.42 IU/L。多因素分析显示年龄是影响免疫应答的主要因素(P<0.05),抗-HBs阳转率以16岁~组最高,为88.46%,其次是25岁~组,为41.30%。二分类Logistic回归分析显示,16岁~、25岁~组的免疫应答效果好于其他年龄组(P<0.01)。结论成人接种单剂60μg Hep B免疫应答效果一般,在不同年龄人群中16~<25岁组免疫效果良好。年龄越小,免疫应答效果越佳。
Objective To analyze the effect of single Hepatitis B vaccine (Hep B) and its influencing factors in adults. Methods A total of 1 678 adults aged 16-54 years were enrolled in this study. Quantitative detection of serum HBsAg, anti-HBs and anti-HBc were performed before immunization. 980 of them, negative for 3 of them, were given Hep B1 60 μg and tested one month after the immunization Anti-HBs were analyzed for anti-HBs positive rate and titer levels. Results The anti-HBs positive rate was 19.39% at 1 month after immunization in 980 mice, and the geometric mean titer was 3.42 IU / L. Multivariate analysis showed that age was the major factor influencing immune response (P <0.05). The positive rate of anti-HBs was highest in patients aged 16 to 88.46%, followed by those aged 25 to 41.30%. Binary Logistic regression analysis showed that the immune response of 16 ~ 25 years old group was better than other age groups (P <0.01). Conclusion Adult immunized with a single dose of 60μg Hep B had an effect of general immune response. The immunization effect was good in 16 ~ <25 years of age group. The younger, the better the immune response.