论文部分内容阅读
本文采用ConA活化小鼠脾细胞~(125)I—UdR掺入法,对111例各型乙肝病毒(HBV)感染者外周血单个核细胞(PBMC)诱生的白细胞介素2(IL-2)活性进行了检测,发现:①除急性肝炎患者和无症状HBsAg携带者外,其他各型HBV感染者IL-2活性均较正常对照组显著降低(P<0.01～0.05),降低程度与临床病型有关;②病毒复制指标(HBeAg、HBV—DNA)阳性组IL-2活性显著低于阴性组(P<0.01)。结果提示IL-2活性的改变在乙型肝炎发病机理中具有重要意义。
In this study, interleukin 2 (IL-2) induced by peripheral blood mononuclear cells (PBMCs) of 111 patients with various types of hepatitis B virus infection was detected by using 125A I-UdR splenocytes in ConA-activated mice. ) Activity was detected and found that: ① Except for acute hepatitis and asymptomatic HBsAg carriers, IL-2 activity in all other types of HBV infection was significantly lower than that in the normal control group (P <0.01 ~ 0.05) (2) The IL-2 activity of HBV replication-positive (HBeAg, HBV-DNA) positive group was significantly lower than that of negative group (P <0.01). The results suggest that the change of IL-2 activity in the pathogenesis of hepatitis B is of great significance.