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目的探讨CD44v6、CD44 (H) 在大肠癌和大肠腺瘤中的表达及与其生物学行为的关系。 方法应用免疫组织化学方法检测 73例大肠癌及 44例大肠腺瘤和肿瘤远切端正常大肠粘膜的CD44v6、CD44 (H) 的表达。结果CD44v6和CD44 (H) 的阳性表达率 :大肠癌 >大肠腺瘤 >肿瘤远切端正常大肠粘膜 ,P均 <0 .0 0 1。CD44v6显示与肿瘤浸润 (Dukes分期 )有明显的相关性 ,P <0 .0 5。在有肿瘤转移组中 ,CD44v6阳性表达率为 86 % (2 4/2 8) ,在无肿瘤转移组CD44v6阳性表达率为 6 0 % (2 7/4 5 ) ,二者相比 ,P <0 .0 5。 结论CD44v6和CD44 (H) 与大肠癌的发生发展过程有关 ,尤其是CD44v6与大肠癌的浸润和转移呈正相关 ,可作为判断大肠癌预后的一种指标。
Objective To investigate the expression of CD44v6 and CD44 (H) in colorectal cancer and colorectal adenoma and its relationship with biological behavior. Methods Immunohistochemistry was used to detect the expression of CD44v6 and CD44 (H) in 73 cases of colorectal cancer and 44 cases of large intestine adenoma and distant normal mucosa of the tumor. Results The positive rates of CD44v6 and CD44 (H) were: colorectal cancer> colorectal adenoma> normal colorectal mucosa at the distal end of the tumor, P < 0.01. There was a significant correlation between CD44v6 and tumor invasion (Dukes stage), P < 0.05. In the group with tumor metastasis, the positive rate of CD44v6 was 86% (2 4/2 8). In the group without tumor metastasis, the positive rate of CD44v6 was 60% (2 7/4 5). Compared with the two groups, P < 0 .0 5. Conclusion CD44v6 and CD44 (H) are associated with the development and progression of colorectal cancer, especially CD44v6 is positively correlated with the invasion and metastasis of colorectal cancer. It can be used as an index to judge the prognosis of colorectal cancer.