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职业性锰中毒主要表现为锥体外系神经障碍,目前国内外尚缺乏特效治疗法,用金属螯合剂促锰排泄,左旋多巴对症治疗.效果均不甚满意。Tandon等曾报导Na-PAS能提高大鼠睾丸和肝乳酸脱氢酶、琥珀酸脱氢酶的活力,促进上二组织病理损害的修复。我院临床观察发现Na-PAS可明显改善锰中毒者自觉症状和体征,为探讨Na-PAS的疗效,我们研究了长期染毒大鼠体内锰分布及Na-PAS对染毒大鼠体内锰分布的影响。实验选用体重220±2g大鼠,雌雄兼用,随机分成七组,饲养于竹笼中,常规消毒下隔日肌注氯化锰。第1～4组给高锰染毒,折合Mn~(2+)量为9 mg/kg,第5～6组行低锰染毒,剂量相当于4 mg/kg Mn~(2+)。第7
Occupational manganese poisoning is mainly manifested as extrapyramidal neurological disorders, the current lack of special treatment at home and abroad, with metal chelators to promote excretion of manganese, levodopa symptomatic treatment. The results are not satisfactory. Tandon et al. Reported that Na-PAS can increase the activity of rat’s testis and liver lactate dehydrogenase, succinate dehydrogenase, and promote the repair of pathological damage in the upper two tissues. Clinical observation in our hospital found that Na-PAS can significantly improve the symptoms and signs of manganese poisoning, in order to explore the efficacy of Na-PAS, we studied the long-term exposure to manganese in rats and Na-PAS on the distribution of manganese in rats Impact. Experimental weight 220 ± 2g rats, both male and female, were randomly divided into seven groups, housed in bamboo cages, routine disinfection next day intramuscular injection of manganese chloride. Groups 1 to 4 were exposed to high manganese, equivalent to 9 mg / kg Mn 2+, and groups 5 to 6 were treated with low manganese at a dose equivalent to 4 mg / kg Mn 2+. 7th