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目的 探讨 5 羟色胺转运体 (SERT)基因多态性在肠易激综合征中的意义。方法 肠易激综合征 (IBS) 81例 ,其中便秘型IBS(C IBS) 30例 ,腹泻型IBS(D IBS) 32例 ,交替型IBS(A IBS) 19例 ,对照组 4 8例。从肠黏膜组织或外周静脉血提取DNA ,采用PCR技术对SERT基因的 2个多态性位点
Objective To investigate the significance of serotonin transporter (SERT) gene polymorphism in irritable bowel syndrome. Methods 81 cases of irritable bowel syndrome (IBS), including 30 cases of constipation IBS (C IBS), 32 cases of diarrhea IBS (D IBS), 19 cases of alternating IBS (IBS) and 48 cases of control group. DNA was extracted from intestinal mucosa tissue or peripheral venous blood. Two polymorphic sites of SERT gene