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目的探索早发性和晚发性帕金森病(PD)合并抑郁各自的临床特点及意义。方法本研究对符合纳入标准的211例PD患者进行回顾性分析,根据起病年龄分为早发组(起病年龄≤50岁)和晚发组(起病年龄>50岁),比较两组患者的临床资料、Hoehn-Yahr分级、UPDRSⅢ评分、老年抑郁量表(GDS)评分、Beck抑郁量表(BDI)评分。结果早发组与晚发组患者Hoehn-Yahr分级、UPDRSⅢ评分比较均差异无统计学意义(P>0.05);早发组与晚发组患者的抑郁患病率、BDI评分、GDS评分和抑郁程度分布差异无统计学意义(P>0.05),但早发组抑郁发生时间要早于晚发组(P<0.05)。早发组的抑郁评分与病程、Hoehn-Yahr分级和UPDRSⅢ评分相关(P<0.05);晚发性组的抑郁评分与起病年龄、Hoehn-Yahr分级和UPDRSⅢ评分相关(P<0.05)。结论早发性PD患者抑郁症状出现时间更早,其抑郁程度与病程、Hoehn-Yahr分级和UPDRSⅢ评分相关。晚发性PD患者抑郁程度与起病年龄、Hoehn-Yahr分级和UPDRSⅢ评分等密切相关。
Objective To explore the clinical features and clinical significance of early-onset and late-onset Parkinson’s disease (PD) combined with depression. Methods A total of 211 PD patients who met the inclusion criteria were retrospectively analyzed. According to the onset age, they were divided into premature onset group (onset age ≤50 years) and late onset group (onset age> 50 years) The patient’s clinical data, Hoehn-Yahr classification, UPDRS III score, Geriatric Depression Scale (GDS) score, Beck Depression Scale (BDI) score. Results There was no significant difference in Hoehn-Yahr grade and UPDRS III score between early onset group and late-onset group (P> 0.05). Prevalence of depression, BDI, GDS and depression There was no significant difference in degree distribution (P> 0.05), but the onset time of depression in early onset group was earlier than that in late onset group (P <0.05). The depression score of early onset group was related to the course of disease, Hoehn-Yahr grade and UPDRS III score (P <0.05). The depression score of late onset group was correlated with age of onset, Hoehn-Yahr grade and UPDRS III score (P <0.05). Conclusions The onset of depressive symptoms in patients with early-onset PD occurs earlier and their depression is related to the course of disease, Hoehn-Yahr grade and UPDRS III score. The degree of depression in patients with late-onset PD is closely related to the age at onset, Hoehn-Yahr grade and UPDRS III score.