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[Pyrhonen S et al:Scand J Infect Dis13(2):95 1981(英文)] 本文报导了用双价流感亚单位疫苗(A/victoria/75和B/Hong Kong/73)与安慰剂以双盲法接种志愿者进行比较观察。疫苗接种组152人,安慰剂组155人。用酶免疫试验(EIA)测定血清抗体。疫苗组接种后3周抗体滴度增加4倍或以上者,甲型为82％,乙型为78％。疫苗组的甲型和乙型流感抗体滴度明显高于对照组(几何平均滴度分别为59.4×10~2对8.3×10~2及35.8×10~2对6.3×10~2)。
[Pyrhonen S et al: Scand J Infect Dis 13 (2): 95 1981 (English)] This paper reports the use of bivalent influenza subunit vaccines (A / victoria / 75 and B / Hong Kong / 73) Law vaccination volunteers for comparative observation. 152 in the vaccination group and 155 in the placebo group. Serum antibodies were measured by enzyme immunoassay (EIA). Three weeks after inoculation of the vaccine group, the antibody titers increased by 4 times or more, 82% for type A and 78% for type B. The titer of influenza A and B antibodies in the vaccine group was significantly higher than that in the control group (geometric mean titers were 59.4 × 10 -2 vs 8.3 × 10 -2 and 35.8 × 10 -2 vs 6.3 × 10 -2, respectively).