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日本九州大学药学教授西岡五夫就中药大黄的化学成分、药理作用进行研究,并发现了其新的生物活性及作用物质。1.泻下作用: ①其主要活性物质是番泻叶甙(sennosi-de); ②泻下是这些番泻叶甙类的协同作用;如sennoside A和C为7:3时,ED_(50)(半数有效量)最强; ③被肠内细菌分解为蒽大黄酸而发挥作用;如番泻叶甙A变成番泻叶素A再变为蒽大黄酸或由番泻叶甙A变为蒽大黄酸糖苷进而变为蒽大黄酸。2.抗菌、抗真菌作用。对革兰氏阴性痢疾、伤寒杆菌,霍乱弧菌及革兰氏阴性葡萄球菌,白喉杆菌,肺炎双球菌等都有抗菌作用。芦荟大黄素、大黄素、大
Professor Nishioka Kazuo, Professor of Pharmacy at Kyushu University in Japan, studied the chemical composition and pharmacological effects of rhubarb, and discovered its new biological activity and acting substances. 1. Purgative effect: 1 Its main active substance is sennosi-de; 2 diarrhea is the synergy of these senna genus; eg sennoside A and C is 7:3, ED_(50) ) (The half effective amount) is the strongest; 3 is decomposed by intestinal bacteria into indosinic acid and functions; for example, senna leafhopper A becomes panaxanthin A and then becomes osmotic rhein or changes from senna leafhopper A For the rhein glycosides, it is further changed to rhein. 2. Antibacterial and antifungal effects. Gram-negative diarrhea, typhoid bacillus, Vibrio cholerae and gram-negative staphylococci, diphtheria bacilli, pneumococcus, etc. have antibacterial effects. Aloe-emodin, emodin, large