First total synthesis of (±)-hypargenin B methyl ether 2 was accomplished via a strategy of ACABC, in which CrO3/H2O/NaOAc/HOAc system was utilized for introducing 7-keto group in order to avoid dehydration of benzyl tertiary alcohol. First total synthesis of (±) -hypargenin B methyl ether 2 was accomplished via a strategy of ACABC, in which CrO 3 / H 2 O / NaOAc / HOAc system was utilized for introducing 7-keto group in order to avoid dehydration of benzyl tertiary alcohol.