目的:探讨C-myc和Maspin蛋白在子宫内膜癌患者血清及癌组织中的表达及其与临床病理特征的关系。方法:子宫内膜癌患者100例,术前及术后7天均空腹取血,采用ELISA法检测患者血清中C-myc和Maspin的蛋白含量。取手术切除的癌组织及癌旁正常组织,采用免疫组织化学技术检测子宫内膜癌患者癌组织中C-myc和Maspin蛋白的表达,分析其表达与子宫内膜癌的临床分期、病理类型及有无淋巴结转移的关系。结果:与术前比较,术后子宫内膜癌患者血清中C-myc蛋白含量降低、Maspin蛋白含量升高,差异有统计学意义(P<0.01);与癌旁正常组织比较,子宫内膜癌组织中C-myc蛋白阳性表达明显升高、Maspin蛋白阳性表达明显降低,差异有统计学意义(P<0.01)。C-myc和Maspin的阳性表达率与临床分期、组织学分级及有无淋巴结转移均有关(P<0.01),C-myc和Maspin在子宫内膜癌中的表达呈负相关性(r=0.592,P<0.05)。结论:C-myc蛋白表达的上调和Maspin蛋白表达的下调可能是子宫内膜癌发生、发展的促进因子,为子宫内膜癌的治疗及预后提供依据。 Objective: To investigate the expression of C-myc and Maspin protein in serum and cancer tissues of patients with endometrial carcinoma and its relationship with clinicopathological features. Methods: 100 cases of endometrial cancer patients were taken fasting blood before operation and 7 days after operation. The contents of C-myc and Maspin in serum were detected by ELISA. C-myc and Maspin proteins were detected by immunohistochemistry in cancerous tissues and adjacent normal tissues. The expression of C-myc and Maspin proteins in endometrial carcinoma tissues were analyzed with the clinical stages, pathological types, With or without lymph node metastasis. Results: Compared with preoperative, the serum levels of C-myc protein and Maspin protein in postoperative patients with endometrial cancer were significantly increased (P <0.01). Compared with normal tissues, endometrium The positive expression of C-myc protein in cancerous tissues was significantly increased, and Maspin protein expression was significantly decreased (P <0.01). The positive expression rates of C-myc and Maspin were correlated with clinical stage, histological grade and lymph node metastasis (P <0.01). The expression of C-myc and Maspin in endometrial carcinoma was negatively correlated (r = 0.592 , P <0.05). Conclusion: The up-regulation of C-myc protein and the down-regulation of Maspin protein may be the promoters for the development and progression of endometrial carcinoma and provide the basis for the treatment and prognosis of endometrial carcinoma.