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目的探索多脏器功能障碍综合征(MODS)出现器官功能障碍顺序及治疗转归差异,研究参麦注射液治疗优势。方法选同时具备呼吸、循环功能障碍的MODS患者40例,随机分对照与治疗两组,治疗组在对照组基础上加用参麦注射液,记录应用多巴胺及机械通气的时间;统计两器官先出现功能障碍及相同时间窗内功能改善、恢复例数。结果先出现呼吸功能障碍例数多于循环功能障碍;且相同时间内循环功能改善、恢复例数多于呼吸功能;两组在应用多巴胺及机械通气的时间上差异有统计学意义。结论 MODS者呼吸功能障碍较循环功能障碍出现早、转归晚;参麦注射液对MODS治疗改善优于单纯连续性静-静脉血液滤过(CVVH)治疗。
Objective To explore the order of organ dysfunction in multiple organ dysfunction syndrome (MODS) and the difference of treatment outcome, and study the advantages of Shenmai injection in treating. Methods Forty patients with MODS with respiratory and circulatory dysfunction were randomly divided into control and treatment groups. The treatment group was given Shenmai injection on the basis of the control group, and the time of applying dopamine and mechanical ventilation was recorded. Dysfunction and functional improvement in the same time window, the number of cases recovered. The results showed that the number of respiratory dysfunction first appeared more than circulatory dysfunction; and at the same time, the circulatory function improved and the number of cases recovered was more than that of respiratory function. There was significant difference between the two groups in the time of applying dopamine and mechanical ventilation. Conclusions Respiratory dysfunction in MODS is earlier than that of circulatory dysfunction and is late. The improvement of MODS is better than that of simple continuous venovenous hemofiltration (CVVH).